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Clinical trials database

Clinical trials in the NAPWHA database are listed below - the most recently-added entries are shown at the top of the list. Click the trial name for more information about that trial.

Rollover Tipranavir and Ritonavir Trial

Clinical trial • Reported • 28 March 2008

A Long Term Open Label Rollover Trial Assessing the Safety and Tolerability of Combination Tipranavir and Ritonavir Use in HIV-1 Infected Subjects
Tags: optimised background regimens

Intensification study (raltegravir and bovine colostrum) CORAL

Clinical trial • No longer enrolling • 26 February 2008

A randomized, double-blind, placebo controlled multi-centre study to measure the effect on CD4+ outcomes of combination antiretroviral therapy (cART) intensification with or without passive immunotherapy to reduce immune activation in HIV infected individuals with persistent CD4+ T-cell count of less than 350 cells despite prolonged HIV plasma viraemia of less than 50 copies for at least 12 months on combination antiretroviral therapy.

ALTAIR (Truvada for treatment-naive)

Clinical trial • Reported • 11 May 2007

A Randomised Open-Label Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection
Tags: first-line therapy, starting treatments

BLQ study (darunavir plus enfuvirtide)

Clinical trial • Reported • 11 May 2007

An Open-Label Study to Evaluate the Effect on Viral Load of a New Investigational Protease Inhibitor With Fuzeon Plus a Background Antiretroviral Regimen in Triple-Class Treatment-Experienced Patients With HIV-1 Infection
Tags: optimised background regimens

NGX-4010 (neuropathy treatment)

Clinical trial • Reported • 11 May 2007

A Multicentre randomized, double-blind, controlled study of NGX-4010 for the treatment of painful HIV-Associated Neuropathy
Tags: peripheral neuropathy, treatment side effects

HIV/HBV coinfection and liver disease

Clinical trial • Enrolling • 11 May 2007

Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) co-Infection and Liver Disease
Tags: hepatitis B, liver disorders

CCR5 inhibitor trial: maraviroc (treatment experienced)

Clinical trial • Reported • 11 May 2007

Trial of Maraviroc (UK-427,857) in Combination With A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of a Novel CCR5 Antagonist, UK-427,857, in Combination With Optimized Background Therapy Versus Optimized Background Therapy Alone for the Treatment of Antiretroviral-Experienced HIV-1 Infected Subjects
Tags: optimised background regimens, resistance tests

CCR5 inhibitor trial: maraviroc (treatment-naive)

Clinical trial • No longer enrolling • 11 May 2007

Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/Lamivudine

STALWART: Interleukin-2 with and without antiretroviral therapy

Clinical trial • Reported • 11 May 2007

A randomized, Open-Label, Phase II, International Study of Subcutaneous Recombinant Interleukin-2 (Proleukin) with and without Concomitant Antiretroviral Therapy in patients with HIV-1 Infection and CD4+ Cell Counts greater than or equal to 300/mm3

PHAEDRA

Clinical trial • Fully enrolled • 11 May 2007

A prospective cohort of individuals with primary HIV infection to determine immunological, virological and therapeutic factors related to disease progression
Tags: primary HIV infection

Abacavir hypersensitivity study

Clinical trial • Reported • 11 May 2007

Identification of susceptibility to abacavir hypersensitivity reaction (HSR) in HIV-1 infected patients in Sydney, Australia and Development of Mechanisms for Risk Reduction
Tags: HLA-B*5701, hypersensitivity reactions

AVX-201E (apricitabine) extension study

Clinical trial • Concluded • 11 May 2007

An open-label extension study to evaluate the long-term safety and efficacy of apricitabine in controlling Human Immunodeficiency Virus (HIV) viral load and disease progression in treatment-experienced HIV-1 infected subjects

BITE (nutritional supplement)

Clinical trial • No longer enrolling • 11 May 2007

The effect of a food product on the immune system of HIV positive adults who do not use HIV inhibitors
Tags: nutrition

Predictors of drug hypersensitivity

Clinical trial • Enrolling • 11 May 2007

Predictors of Drug Hypersensitivity in HIV-infected subjects
Tags: hypersensitivity reactions

SPARTAC (early intervention)

Clinical trial • Fully enrolled • 11 May 2007

A Multi-centre Randomised Trial of Therapeutic Intervention at Primary HIV-1 Infection
Tags: newly diagnosed, starting treatments