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Clinical trials database - open trials

Open clinical trials in the NAPWA database are listed below – the most recently-added entries are shown at the top of the list.

(‘Open’ clinical trials are those listed as enrolling now or not yet started.)

ENCORE-1

Clinical trial • Enrolling • 27 June 2008

A Randomised, Double-blind, Placebo-controlled, Clinical Trial to Compare the Safety and Efficacy of Reduced Dose Efavirenz (EFV) With Standard Dose EFV Plus Two Nucleotide Reverse Transcriptase Inhibitors (N(t)RTI) in Antiretroviral-naïve HIV-infected Individuals Over 96 Weeks
Tags: clinical trials

MODERN (Maraviroc versus Truvada)

Clinical trial • Enrolling • 19 January 2012

A Multicenter, Randomized, Double Blind, Comparative Trial Of Maraviroc + Darunavir/Ritonavir Versus Emtricitabine/Tenofovir +Darunavir/Ritonavir For The Treatment Of Antiretroviral-Naïve HIV Infected Patients With Ccr5 Tropic HIV 1
Tags: maraviroc

Lersivirine long term safety study

Clinical trial • Enrolling • 25 March 2011

A Long Term Open-Label Extension Study of Lersivirine For The Treatment Of HIV-1 Infection

Cobicistat and renal function

Clinical trial • Enrolling • 16 January 2012

A Phase 3 Open-label Safety Study of Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

CVD risk reduction

Clinical trial • Enrolling • 23 November 2011

Effectiveness of Team Intervention Over 12 Months in Reducing Modifiable CVD Risk Factors on Framingham 10yr Risk Scores Outcomes in HIV-1 Subjects on Antiretroviral Therapy

CNS HAND

Clinical trial • Enrolling • 23 November 2011

The CNS HAND Study: The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort

ATRAS

Clinical trial • Enrolling • 19 October 2011

AHOD Temporary Residents Access Study

MARCH

Clinical trial • Enrolling • 18 October 2011

A randomised, open-label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for either nucleoside or nucleotide analogue reverse transcriptase inhibitors (N(t)RTI) or boosted protease inhibitors (PI/r) in HIV-1 infected individuals with stable, well-controlled plasma HIV-RNA while taking their first N(t)RTI + PI/r regimen of combination antiretroviral therapy (cART)

START (Strategic Timing of AntiRetroviral Treatment)

Clinical trial • Enrolling • 9 April 2009

Strategic Timing of AntiRetroviral Treatment (START)
Tags: starting treatments

SAILING

Clinical trial • Enrolling • 3 November 2010

A Randomized, Double-blind Study of the Safety and Efficacy of GSK1349572 50 mg Once Daily Versus Raltegravir 400 mg Twice Daily, Both Administered With an Investigator-selected Background Regimen Over 48 Weeks in HIV-1 Infected, Integrase Inhibitor-Naïve, Antiretroviral-Experienced Adults

ROaR+

Clinical trial • Enrolling • 24 March 2011

Post-prandial Lipid Effects of Raltegravir (RAL) vs Ritonavir-boosted Darunavir (DRV-r) in Anti-retroviral Therapy (ART)-Naive Adults
Tags: heart disease

Second line

Clinical trial • Enrolling • 26 June 2008

A Randomised Open-label Study Comparing the Safety and Efficacy of Ritonavir Boosted Lopinavir and 2-3N(t)RTI Backbone Versus Ritonavir Boosted Lopinavir and Raltegravir in Participants Virologically Failing First-line NNRTI/2N(t)RTI Therapy
Tags: first-line therapy, salvage therapy

Treating influenza

Clinical trial • Enrolling • 19 February 2010

A Randomized Open Label Study Comparing the Efficacy, Safety, and Tolerability of Oral Administration of Amantadine and Ribavirin With Oseltamivir Versus Oseltamivir to Influenza A Virus Infected Immunocompromised Subjects
Tags: symptoms, illnesses and opportunistic infections

Pharmacist prescribing study

Clinical trial • Enrolling • 19 February 2010

The Evaluation of the Impacts of a Doctor – Pharmacist Collaborative Prescribing Model on the Management of Human Immunodeficiency Virus (HIV) Infected Patients
Tags: Accessing HIV care and treatment

PHIIDO - disease progression

Clinical trial • Enrolling • 19 February 2010

A prospective cohort study of individuals with primary Human Immunodefiency Virus (HIV) infection to determine immunological and virological factors related to disease progression.
Tags: pathogenesis

Immune responses to hepatitis B

Clinical trial • Unknown • 19 February 2010

Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
Tags: hepatitis B

'Naive T-cell' study

Clinical trial • Unknown • 17 February 2010

Role of Naive T-Cells in the Pathogenesis of T-Cell Decline and Long Term Persistence of HIV
Tags: newly diagnosed, pathogenesis, primary HIV infection

The Structured Treatment Interruption (STI) Study

Clinical trial • Not yet started • 22 October 2008

A Randomized, Multicenter Trial to Determine Whether Induction Therapy Followed by Treatment Interruption is Superior to Induction Therapy Alone in the Treatment of Primary HIV Infection (PHI): The Structured Treatment Interruption (STI) Study

Predictors of drug hypersensitivity

Clinical trial • Enrolling • 11 May 2007

Predictors of Drug Hypersensitivity in HIV-infected subjects
Tags: hypersensitivity reactions

HIV/HBV coinfection and liver disease

Clinical trial • Enrolling • 11 May 2007

Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) co-Infection and Liver Disease
Tags: hepatitis B, liver disorders

HIV/HBV coinfection and tenofovir resistance

Clinical trial • Enrolling • 28 March 2008

A surveillance program for the detection of hepatitis B virus (HBV) resistance to tenofovir (TDF) in HIV-HBV co-infected patients
Tags: hepatitis B

HIV/HBV or HIV/HCV coinfection

Clinical trial • Enrolling • 23 April 2008

A Study of Innate Immunity in HIV Positive Patients co-Infected With Hepatitis C or Hepatitis B
Tags: hepatitis B, hepatitis C, innate immunity