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Clinical trials database - closed trials

Closed clinical trials in the NAPWA database are listed below – the most recently-added entries are shown at the top of the list.

(‘Closed’ clinical trials include those listed as fully enrolled, concluded, or cancelled.)

Single

Clinical trial • No longer enrolling • 14 March 2011

A Randomized, Double-Blind Study of the Safety and Efficacy of GSK1349572 Plus Abacavir/Lamivudine Fixed-Dose Combination Therapy Administered Once Daily Compared to Atripla Over 96 Weeks in HIV-1 Infected Antiretroviral Therapy Naive Adult Subjects

UK-453, 061

Clinical trial • Concluded • 24 March 2009

A Study Of Different Doses Of UK-453, 061 Plus Truvada Compared To Efavirenz Plus Truvada In Patients Who Have Not Been Previously Treated For HIV-1
Tags: drug resistance, NNRTI

ALTAIR (Truvada for treatment-naive)

Clinical trial • Reported • 11 May 2007

A Randomised Open-Label Study Comparing the Safety and Efficacy of Three Different Combination Antiretroviral Regimens as Initial Therapy for HIV Infection
Tags: first-line therapy, starting treatments

CMV and interferon

Clinical trial • Concluded • 17 February 2010

Evaluation of Interferon-Gamma Responses to HCMV Infection in HIV Positive Individuals
Tags: CMV, symptoms, illnesses and opportunistic infections

RETRIeVE

Clinical trial • Fully enrolled • 24 January 2012

Non-nucleoside Reverse Transcriptase Inhibitor Failure in a High HIV Caseload Australian Primary Care Practice

Gardasil for young men

Clinical trial • Reported • 16 January 2012

An Investigational Vaccine in Reducing the Incidence of Anogenital Warts in Young Men
Tags: anal cancer, HPV

SPARTA

Clinical trial • Concluded • 21 August 2009

A Randomised, Open-Label, Cross-Over Study to Examine the Pharmacokinetics and Short-Term Safety and Efficacy of Two Dosing Strategies of Raltegravir Plus Atazanavir in HIV-Infected Patients
Tags: atazanavir, first-line therapy, raltegravir

SPRING 2

Clinical trial • No longer enrolling • 3 November 2010

A Randomized, Double Blind Study of the Safety and Efficacy of GSK1349572 50mg Once Daily to Raltegravir 400mg Twice Daily Both Administered With Fixed-dose Dual Nucleoside Reverse Transcriptase Inhibitor Therapy Over 96 Weeks in HIV-1 Infected Antiretroviral Therapy Naive Adult Subjects

TMC125 (etravirine) for people who failed on the DUET studies

Clinical trial • Reported • 10 May 2007

An Open-Label Trial with TMC125 in Patients Who Have Virologically Failed in a DUET Trial (TMC125-C206 or TMC125-C216)

Impact of HIV and Its Treatment on Reverse Cholesterol Transport

Clinical trial • No longer enrolling • 22 October 2008

Impact of HIV Infection and Treatment With Highly Active Antiretroviral Therapy on Reverse Cholesterol Transport
Tags: heart disease

PINT (including raltegravir)

Clinical trial • Fully enrolled • 11 April 2008

The Effect of Raltegravir on HIV Decay During Primary and Chronic Infection (PINT)

Rapid Testing

Clinical trial • Fully enrolled • 24 March 2011

Do homosexual men test more frequently for human immunodeficiency virus (HIV) with rapid tests? A randomised controlled trial.

'Booster' study

Clinical trial • No longer enrolling • 3 August 2010

Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of GS-9350-boosted Atazanavir Versus Ritonavir-boosted Atazanavir Each Administered With Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

QUAD

Clinical trial • No longer enrolling • 21 May 2010

A Phase 3, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Elvitegravir/Emtricitabine/Tenofovir Disoproxil Fumarate/GS-9350 Versus Ritonavir-Boosted Atazanavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults

TROP - low bone mineral density

Clinical trial • No longer enrolling • 22 January 2010

Switch From Tenofovir to Raltegravir for Low Bone Mineral Density
Tags: bone disorders, integrase inhibitor, raltegravir

ATAHC: Australian trial in acute hepatitis C

Clinical trial • Reported • 29 April 2008

Australian Trial in Acute Hepatitis C
Tags: hepatitis C, liver disorders

VERxVE (fast and slow release nevirapine)

Clinical trial • Fully enrolled • 28 March 2008

A Randomised, Double Blind, Double Dummy, Parallel Group, Active Controlled Trial to Evaluate the Antiviral Efficacy of 400 mg QD Nevirapine Extended Release Formulation in Comparison to 200 mg BID Nevirapine Immediate Release in Combination With Truvada? in Antiretroviral Therapy Naive HIV-1 Infect
Tags: liver disorders, optimised background regimens, treatment side effects

TMC278 (rilpivirine) versus efavirenz (2 trials)

Clinical trial • Concluded • 22 October 2008

A Phase III, Randomized, Double-Blind Trial of TMC278 25mg q.d. Versus Efavirenz 600mg q.d. in Combination With a Background Regimen Containing 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Antiretroviral-Naive HIV-1 Infected Subjects >>>>> AND <<<< A Phase III, Randomized, Double-Blind Trial of TMC278 25 mg q.d. Versus Efavirenz 600mg q.d. in Combination With a Fixed Background Regimen Consisting of Tenofovir Disoproxil Fumarate and Emtricitabine in Antiretroviral-Naive HIV-1 Infected Subjects.

Elvitegravir versus raltegravir

Clinical trial • No longer enrolling • 22 October 2008

A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Ritonavir-Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL) Each Administered With a Background Regimen in HIV-1 Infected, Antiretroviral Treatment-Experienced Adults
Tags: Elvitegravir, integrase inhibitor, raltegravir

Flupirtine for HIV sensory neuropathy

Clinical trial • Concluded • 8 April 2009

A one-year, open label, extension study of flupirtine for the treatment of painful HIV-sensory neuropathy in patients who have pain inadequately controlled by opioids
Tags: peripheral neuropathy

GB Virus C, HIV and HCV

Clinical trial • Reported • 17 February 2010

Associations, Outcomes and Genomics of GB Virus C, Hepatitis C Virus and Human Immunodeficiency Virus Infection
Tags: hepatitis C, hepatotoxicity, liver disorders, symptoms, illnesses and opportunistic infections

Immune responses to hepatitis B

Clinical trial • Unknown • 19 February 2010

Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
Tags: hepatitis B

'Naive T-cell' study

Clinical trial • Unknown • 17 February 2010

Role of Naive T-Cells in the Pathogenesis of T-Cell Decline and Long Term Persistence of HIV
Tags: newly diagnosed, pathogenesis, primary HIV infection

AVX-754

Clinical trial • Concluded • 17 February 2010

A Phase II, Randomised, Double-blind, Dose-ranging Study of AVX754 Versus Lamivudine in Treatment-experienced HIV-1 Infected Patients With the M184V Mutation in Reverse Transcriptase
Tags: drug resistance, NRTI

STEP HIV vaccine study

Clinical trial • Cancelled • 10 May 2007

A multicentre, Double-Blind, Randomised, Placebo-Controlled Phase II Proof-of-Concept Study to Evaluate the Safety and Efficacy of a 3-Dose Regimen of the Merck Adenovirus Serotype-5 HIV-1 Vaccine gag/pol/nef (MRKad5 HIV-1 gag/pol/nef in Adults at High Risk of HIV-1 Infection
Tags: preventative vaccines, Safe sex