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Fosamprenavir

telzir.jpg

Fosamprenavir is suitable for those both treatment-experienced and treatment-naive. It has proved to be as effective as other protease inhibitorsA type of anti-HIV drug that works by preventing the production of an enzyme, protease, that HIV needs to replicate., with or without ritonavir boosting, in patients who have not taken antiretroviralA medication or other substance which is active against retroviruses such as HIV. therapy before.

Fosamprenavir itself is not active in the body but it converts into amprenavir in the gut which is then active against HIV.

Generic name: fosamprenavir (FPV)
Pronunciation:FOSS-am-pren-aveer
Brand name:Telzir
Also known as:GW-433908
Lexiva
Drug class:protease inhibitor
Pediatric dosing?Available in doses suitable for children and/or young people.
Availability in Australia:
  • Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers.
  • This drug may be available through clinical trials in Australia.
  • You may be able to import this drug from overseas for your personal use.
Presentation:700mg tablet
What the treatment guidelines say:There are limited data regarding the use of twice-daily boosted fosamprenavir with nucleoside/nucleotide combinations other than abacavir/lamivudine.
Links:

Like most anti-HIV drugs, fosamprenavir must be taken in combination with other drugs to be completely effective. Commonly, fosamprenavir is combined with two nucleoside (NRTI) drugs, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.

Dosage

The normal daily dose is one 700mg tablet plus 100mg ritonavir twice a day

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.

With or without food?

Fosamprenavir may be taken with or without food.

Side effects

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.

  • Common side effects may include nausea (upset stomach, feeling sick to the stomach), diarrhoea, vomiting, headache, rash.
  • Less common side effects may include abdominal pain, numbness around the mouth, hyperlipidemia.
  • Rare side effects may include skin reactions, including Stevens-Johnson syndrome.

    • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

Drugs to watch out for include other antiretrovirals and drugs to treat tuberculosis, erectile dysfunction (such as Viagra), heart rhythm (antiarrhythmics) and migraine headaches. Interactions are also possible with several antihistamines, sedatives, drugs to lower cholesterol and anti-fungal drugs. Fosamprenavir should not be combined with Kaletra as levels of both lopinavir and fosamprenavir are reduced in the blood. If fosamprenavir is taken with ritonavir and efavirenz, the daily dosage of ritonavir may need to be increased. Some birth control pills may not work if you are taking fosamprenavir. Fosamprenavir causes major increases in blood levels of some antidepressants like Elavil and Tofranil. These drugs are sometimes used to treat peripheral neuropathy. However, fosamprenavir decreases blood levels of paroxetine, an antidepressant. A dose increase of paroxetine may be needed. Discuss use of antidepressants with your doctor. Fosamprenavir levels do not appear to be affected by use of antacids. Taking fosamprenavir with methadone can lower blood levels of both drugs. Check with your doctor if you use methadone. Watch for signs of excessive sedation with buprenorphine. The herb St. John's wort lowers the blood levels of some protease inhibitors. Do not take it while taking fosamprenavir. Fosamprenavir increases blood levels of several "statin" drugs used to lower cholesterol levels. Some statins should not be used. The dose of others should be reduced.
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Fosamprenavir linked to cardio risk

Positive Living article • 20 August 2009

A French case-control study has reported an association between exposure to fosamprenavir and an increased risk of heart attackA life-threatening emergency in which the blood supply to the heart is suddenly cut off, causing the heart muscle (myocardium) to die from lack of oxygen.. This may be related to the propensity for this drug classA group of anti-HIV drugs with the same target of action. Anti-HIV drug classesA group of anti-HIV drugs with the same target of action. Anti-HIV drug classes include nucleoside analogue reverse transcriptase inhibitors, protease inhibitors and non-nucleoside analogue reverse transcriptase inhibitors, as well as several others. Combining drugs from three or more classes is the basis of Highly Active Antiretroviral Therapy (HAART). include nucleoside analogue reverse transcriptase inhibitors, protease inhibitors and non-nucleoside analogue reverse transcriptase inhibitors, as well as several others. Combining drugs from three or more classes is the basis of Highly Active AntiretroviralA medication or other substance which is active against retroviruses such as HIV. Therapy (HAARTHighly Active AntiRetroviral Therapy ??? aggressive treatment of HIV infection using several different drugs together.). to raise blood lipids. read more »

Triple treat

Positive Living article • Paul Kidd • 15 October 2004

The Pharmaceutical Benefits Scheme[Pharmaceutical Benefits Scheme] The federal government program which subsidises medication costs in Australia. Anti-HIV drugs are part of a special part of the PBS called Section 100 (S100) which is used for expensive, highly specialised drugs. has recently added three new antiretroviralsA medication or other substance which is active against retroviruses such as HIV., to become available on prescription in December. PAUL KIDD takes a look at the newest weapons in the anti-HIV armoury. read more »

Bangkok AIDS Conference: Small steps

Positive Living article • Paul Kidd • 15 August 2004

There isn’t a lot of Earth-shattering news to report from Bangkok, but as always there were numerous small developments. As PAUL KIDD explains, some of these small steps could develop into giant leaps. read more »

The power of one

Positive Living article • Paul Kidd • 15 December 2003

We all want simpler treatment regimens with fewer side effects and no meal restrictions, right? Well how does once-a-day treatment sound? As PAUL KIDD reports, it may be closer than you think. read more »

2001 European HIV conference, Athens

Story • Kirsty Machon • 28 October 2001

A report from the 8th European Conference on the ClinicalPertaining to or founded on observation and treatment of participants, as distinguished from theoretical or basic science. Aspects and Treatment of HIV Infection, held in Athens, Greece in October, 2001. read more »

The table below shows all the clinical trials in the database with the keyword fosamprenavir/amprenavir.

Sorry, no clinical trials database entries were found that matched your request.

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This Treatments database entry was first published on 2 June 2009 — more than two years ago.

While the content of this treatments database entry was checked for accuracy at the time of publication, NAPWA recommends checking to determine whether the information is the most up-to-date available, especially when making decisions which may affect your health.

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